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The Major Gastrointestinal Regulatory Substances
主要腸胃荷爾蒙及神經調節物質
SUBSTANCE 物質 | STIMULUS FOR PRODUCTION 刺激其產生的因素 | TARGET TISSUE 標的組織 | EFFECT ON SECRETIONS 分泌物的效果 | EFFECT ON MOTILITY 對腸胃道蠕動之效果 |
A. Neuroregulators 神經傳遞調節物質 | ||||
Acetylcholine 乙酸酸膽鹼 | Sight, smell, chewing food, stomach distention 視覺、嗅覺、咀嚼食物、胃擴張 | Gastric glands, other secretory glands, gastric and intestinal muscle 胃腺體、分泌腺體、胃及小腸肌肉 | Increased gastric acid 增加胃酸 | Generally increased; decreas sphincter tone 通常增加胃腸蠕動、降低括約肌張力 |
Norepinephrine 正腎上腺素 | Stress, other various stimuli 壓力、其它各種刺激 | Secretory glands, gastric and intestinal muscle 分泌腺體、胃及小腸肌肉 | Generally inhibitory 通常為抑制 | Generally decreased; increase sphincter tone 通常降低胃腸蠕動,增加括約肌張力 |
B. Hormonal Regulators 荷爾蒙調節物質 | ||||
Gastrin 促胃液素 | Stomach distention with food 胃因有食物而擴張時 | Gastric glands 胃腺體 | Increased secretion of gastric juice, which is rich in HCI 增加富含塩酸的胃液分泌 | 1. Increased motility of stomac decreased time required for gastric emptying 增加胃之蠕動,降低胃排空時間 2. Relaxation of ileocecal sphincter 鬆弛迴盲括約肌 3. Excitation of colon 刺激興奮大腸 4. Constriction of gastroesophageal sphincter 胃食道括約肌收縮 |
Cholecystokinin 胆囊收縮素 | Fat in duodenum 十二指腸中的脂肪 | Gallbladder 胆囊 | Release of bile into duodenum 釋放胆汁進入十二指腸 | |
Pancreas 胰 | Increased production of enzyme rich pancereatic secretions 增加分泌富含酶的胰分泌液 | |||
Stomach 胃 | Inhibits gastric secretion somewhat 抑制胃之分泌 | |||
Secretin 胰泌素 | pH of chyme in duodenum below 4-5 十二指腸中的食糜之 pH 低於4-5時 | Stomach 胃 | Inhibits gastric secretion somewhat 抑制胃之分泌 | Inhibits stomach contractions 抑制胃收縮 |
Pancreas 胰 | Increased production of bicarbonate-rich pancreatic juice 增加分泌富含碳酸的胰液 | |||
C. Local Regulator 局部調節物質 | ||||
Histamine 組織胺 | Unclear, substances in food 不明食物中的成份 | Gastric glands 胃腺體 | Increased gastric acid production 增加胃酸分泌 |
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